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It was a time of world exploration and Europeans took the disease to Calcutta in 1498, and by 1520 it had reached Africa, the near East, China, Japan and Oceania. Command=Doc Name&File=Osleriana&Name=Internal Medicine as a Vocation , accessed on 6.6.12.[5] Syphilis had a variety of names, usually people naming it after an enemy or a country they thought responsible for it. [3] The impact of gonorrhoea and syphilis on military personnel in terms of morbidity and mortality was greatly mitigated after 1943 due to the introduction of penicillin, as well as other factors such as education, prophylaxis, training of health personnel and adequate and rapid access to treatment.

On Charles’ return to France the army disbanded and the soldiers and their camp followers took the disease with them back to their respective homelands.They often extended into the mouth and throat, and sometimes early death occurred.It appears from descriptions by scholars and from woodcut drawings at the time that the disease was much more severe than the syphilis of today, with a higher and more rapid mortality and was more easily spread , possibly because it was a new disease and the population had no immunity against it.[1] Johannis (Giovanni) de Vigo, an Italian surgeon who was appointed as surgeon to Pope Julius II, wrote about the contagiousness of the disease, its origin from sexual intercourse with an infected person and its rapid dissemination throughout the body in De Morbo Gallicus, 1514, the fifth book of his work Practica in arte chirurgica copiosa. He accurately described the primary chancre, the secondary eruption of rash, ulcers and pustules, the terrible night bone pains and the late “tumours of scirrhus hardness”.

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